In vivo characterization of metabotropic glutamate receptor type 5 abnormalities in behavioral variant FTD

Title : Metabotropic glutamate receptor 5 : a candidate

Background: Pharmacological modulation of metabotropic glutamate receptor 5 (mGluR5) is of marked interest as a novel therapeutic mechanism to treat schizophrenia and major depression. However, the status of mGluR5 in the pathophysiology of these disorders remains unknown. Discussion: The majority of studies in the schizophrenia post-mortem brain indicate that total mGluR5 expression is unalter...

Behavioral effects of the selective blockade of metabotropic glutamate receptor subtype 5 in experimental hypoxia.

The behavioral activity of 2-methyl-6-(phenylethynyl)-pyridine (MPEP), a selective antagonist of metabotropic glutamate receptor subtype 5 (mGluR5), was assesed in control groups of rats and in rats that underwent short-term hypoxia. MPEP applied intravenously (iv) at the dose of 1 mg/kg was tested using the open field test, the passive avoidance test and the elevated "plus" maze test. MPEP sig...

P6: Metabotropic Glutamate Receptor-Dependent Role in the Formation of Long-Term Potentiation

Long-term potentiation (LTP) is a reflection of synaptic plasticity that induced by specific patterns of synaptic activity and has an important role in learning and memory. The first clue of the potential role of glutamate receptors in LTP was in 1991 with the observation that the mGluR agonists 1-amino-1, 3-cyclopentanedicarboxylic acid (ACPD), increased LTP. Studies have shown that ACPD induc...

A novel metabotropic glutamate receptor 5

Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence.

Posttraumatic stress disorder (PTSD) is a prevalent and highly disabling disorder, but there is currently no targeted pharmacological treatment for it. Dysfunction of the glutamate system has been implicated in trauma and stress psychopathology, resulting in a growing interest in modulation of the glutamate system for the treatment of PTSD. Specifically, the metabotropic glutamate receptor 5 (m...